grant PAR-25-153

Assay development & screening to discover small-molecule cancer probes or drugs (R01 — no clinical trials)

The NCI R01 supports discovery-stage projects to design and validate primary screening assays, implement high- or moderate-throughput screens (including virtual screening), and perform hit validation to identify small-molecule chemical probes or therapeutic leads targeting tumor cells or tumor-regulating immune cells. Applicants should focus on one or two stages with strong feasibility or prel…

Through this Notice of Funding Opportunity (NOFO), the National Cancer Institute (NCI) intends to support discovery research for the identification of small molecules that function to elucidate the biology of cancer as chemical probes or function as activators or inhibitors of cancer target(s) f…

Funding Source

Agency: National Institutes of Health
Sub-agency: National Cancer Institute

Eligibility

Nonprofits (Other than Institutions of Higher Education) – without 501(c)(3) IRS Status
Regional Organizations
Higher Education Institutions – Private Institutions of Higher Education
For-Profit Organizations – Other than Small Businesses
Federal Government – Eligible agencies of the Federal Government
U.S. Territories or Possessions
Independent School Districts
Public Housing Authorities/Indian Housing Authorities
Native American Tribal Organizations (other than Federally recognized tribal governments)
Faith-based or Community-based Organizations
Non-domestic (non-U.S.) Entities (Foreign Organizations)

  • Foreign eligibility: Non-domestic (non-U.S.) entities (foreign organizations) are eligible to apply. Non-domestic (non-U.S.) components of U.S. organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
  • Required registratio…

Dates

Opportunity Released: November 6, 2024
Open for Submission: November 6, 2024
Submission Deadline: September 7, 2026
Application Window Closes: September 7, 2026

Supporting links

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