Scout | PAR-25-198: Developing next-generation human nervous system microphysiological systems (R01, no clinical trials)

This opportunity is no longer accepting applications.

grant PAR-25-198

Developing next-generation human nervous system microphysiological systems (R01, no clinical trials)

Summary

This R01 NOFO supports technology-focused research to develop advanced human cell–derived microphysiological systems (e.g., organoids, tissue chips, xenografts) that better replicate brain, spinal cord, or sensory circuit maturation, connectivity, and long-term function. Projects should prioritize improving physiological fidelity, robustness, and reproducibility of circuit-level readouts rathe…

Human cell-based assays (e.g., using induced pluripotent stem cells) hold promise for identifying molecular, cellular, and circuit defects, identifying novel targets and developing new therapeutics for patients with complex brain and other nervous system disorders. However, the methods to genera…

Funding Source

Agency: National Institute on Aging

Sub-agency: National Institutes of Health

Awards & funding

Eligibility

Higher Education Institutions – Public/State-controlled Institutions of Higher Education

Higher Education Institutions – Private Institutions of Higher Education

Nonprofits (Other than Institutions of Higher Education) – with 501(c)(3) IRS Status

Nonprofits (Other than Institutions of Higher Education) – without 501(c)(3) IRS Status

For-Profit Organizations – Small Businesses

For-Profit Organizations – Other than Small Businesses

State Governments

County Governments

City or Township Governments

Special District Governments

Local Governments (general)

Indian/Native American Tribal Governments (Federally Recognized)

Indian/Native American Tribal Governments (Other than Federally Recognized)

Federal Government (Eligible Agencies of the Federal Government)

U.S. Territories or Possessions

Independent School Districts

Public Housing Authorities/Indian Housing Authorities

Native American Tribal Organizations (other than Federally recognized tribal governments)

Faith-based or Community-based Organizations

Regional Organizations

Non-domestic (non-U.S.) Entities (Foreign Organizations)

Non-domestic (non-U.S.) components of U.S. Organizations

Other (unspecified)

Foreign entities: Non-domestic (non-U.S.) entities (foreign organizations) are eligible to apply. Non-domestic (non-U.S.) components of U.S. organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
Required registrations …

Dates

Opportunity Released: November 6, 2024

Open for Submission: November 6, 2024

Submission Deadline: January 7, 2026

Application Window Closes: January 7, 2026

Supporting links

National Institutes of Health

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