grant PAR-25-183

Early-Stage R33 Trials for Pharmacologic or Neuromodulatory Device Treatments for Mental Illness (Clinical Trial Required)

This NOFO funds single-phase, early-stage clinical trials testing pharmacologic agents with novel mechanisms or neuromodulatory devices to treat symptoms or functional domains in people with mental illness, including prodromal cases. Proposals must test the presumed mechanism of action and demonstrate dose-dependent neurophysiological, clinical, or behavioral effects. Studies may target pediat…

In the last several years, pharmaceutical companies have shifted their focus away from psychiatric indications, due to the high failure rate of drug approvals, with many of the failures occurring in late stage development after significant funding and testing had occurred. Likewise, a handful of…

Funding Source

Agency: National Institutes of Health
Sub-agency: National Institute of Mental Health

Awards & funding

Total Funding: $27M

Eligibility

U.S. Territories and Possessions
Independent School Districts
Public Housing Authorities/Indian Housing Authorities
Faith-based Organizations
Community-based Organizations
Regional Organizations
Foreign Organizations (Non-domestic entities)
Native American Tribal Organizations (other than Federally recognized tribal governments)
Private Institutions of Higher Education
Nonprofits without 501(c)(3) IRS Status (Other than Institutions of Higher Education)
For-Profit Organizations (Other than Small Businesses)
Federal Government (Eligible Agencies of the Federal Government)

  • Foreign entities: Non-domestic (non-U.S.) entities (foreign organizations) are eligible to apply. Non-domestic (non-U.S.) components of U.S. organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
  • Required registrations …

Dates

Opportunity Released: November 26, 2024

Supporting links

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