In-Depth Phenotyping and Research Using IMPC-Generated Knockout Mouse Strains Exhibiting Embryonic or Perinatal Lethality or Subviability (R01 Clinical Trial Not Allowed)
The IMPC aims to create a comprehensive catalog of mammalian gene functions to support the study of human genetic variations. As of July 19, 2022, they have released phenotypic data for 8,260 knockout genes. The goal is to generate and study null mutants for every gene in the mouse genome. Around 30% of these mouse strains are expected to be non-viable at the embryonic or perinatal stages or h…
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