Scout | PAR-25-140: In-Depth Phenotyping and Research Using IMPC-Generated Knockout Mouse Strains Exhibiting Embryonic or Perinatal Lethality or Subviability (R01 Clinical Trial Not Allowed)

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grant PAR-25-140

In-Depth Phenotyping and Research Using IMPC-Generated Knockout Mouse Strains Exhibiting Embryonic or Perinatal Lethality or Subviability (R01 Clinical Trial Not Allowed)

Summary

The IMPC aims to create a comprehensive catalog of mammalian gene functions to support the study of human genetic variations. As of July 19, 2022, they have released phenotypic data for 8,260 knockout genes. The goal is to generate and study null mutants for every gene in the mouse genome. Around 30% of these mouse strains are expected to be non-viable at the embryonic or perinatal stages or h…

The purpose of this Notice of Funding Opportunity (NOFO) is two-fold: 1) to encourage submission of applications to do more in-depth phenotyping on investigator-selected cohorts of embryonic lethal or subviable Knockout (KO) mouse strains generated by the International Mouse Phenotyping Consorti…

Funding Source

Agency: National Institutes of Health

Sub-agency: <em>Eunice Kennedy Shriver</em> National Institute of Child Health and Human Development

Awards & funding

Award Ceiling: $499,999

Award Amount: $499,999

Eligibility

U.S. Territory or Possession

Independent School Districts

Public Housing Authorities/Indian Housing Authorities

Faith-based or Community-based Organizations

Regional Organizations

Non-domestic (non-U.S.) Entities (Foreign Organizations)

Non-domestic (non-U.S.) components of U.S. Organizations

Foreign components (as defined in the NIH Grants Policy Statement) are allowed

Higher Education Institutions (Private)

Nonprofits without 501(c)(3) IRS Status (Other than Institutions of Higher Education)

For-Profit Organizations (Other than Small Businesses)

Native American Tribal Organizations (Other than Federally recognized tribal governments)

Federal Government Agencies (Eligible Agencies of the Federal Government)

Foreign/International eligibility: Non-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply. Non-domestic components of U.S. organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
Required registra…

Dates

Opportunity Released: November 6, 2024

Open for Submission: November 6, 2024

Submission Deadline: January 7, 2026

Application Window Closes: January 7, 2026

Supporting links

National Institutes of Health

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