Scout | PAR-25-330: Role of Defective Proviruses in HIV Persistence (R01 Clinical Trial Not Allowed)

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grant PAR-25-330

Role of Defective Proviruses in HIV Persistence (R01 Clinical Trial Not Allowed)

This R01 NOFO seeks research using human samples to define how abundant, replication-incompetent (defective) HIV proviruses—which can express viral RNA and protein—affect immune activation, reservoir dynamics, post-treatment control, and responses to HIV cure strategies. It also supports methods development to identify and exclude defective proviruses from viral-load, bNAb-sensitivity, and dru…

Source

Agency: National Institutes of Health

Sub-agency: National Institute of Allergy and Infectious Diseases

Award

Total Funding: $500,000

Award Ceiling: $500,000

Funding Amount: $500,000

Dates

Opportunity Released: December 9, 2024

Expiration Date: February 19, 2026

Eligibility

University

Nonprofit

Small business

Tribal

Government

Higher Education Institutions – Private Institutions of Higher Education

Nonprofits (Other than Institutions of Higher Education) – without 501(c)(3) IRS Status

For-Profit Organizations – Other than Small Businesses

County Governments

City or Township Governments

Special District Governments

Native American Tribal Organizations (other than Federally recognized tribal governments)

Federal Government – Eligible Agencies of the Federal Government

U.S. Territory or Possession

Independent School Districts

Public Housing Authorities/Indian Housing Authorities

Faith-based or Community-based Organizations

Regional Organizations

Non-domestic (non-U.S.) Entities (Foreign Organizations)

Non-domestic (non-U.S.) components of U.S. Organizations

Foreign components (as defined in NIH Grants Policy Statement) are allowed

Keywords

defective proviruses

hiv reservoir

viral persistence

immune activation

assay development

bnab sensitivity

epitope mapping

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Documents

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