Scout | PAR-25-330: Defective HIV Proviruses: Impact on Persistence, Immunity, and Cure-Related Assays (R01, Clinical Trial Not Allowed)

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grant PAR-25-330

Defective HIV Proviruses: Impact on Persistence, Immunity, and Cure-Related Assays (R01, Clinical Trial Not Allowed)

Summary

This R01 NOFO seeks research using human samples to define how abundant, replication-incompetent (defective) HIV proviruses—which can express viral RNA and protein—affect immune activation, reservoir dynamics, post-treatment control, and responses to HIV cure strategies. It also supports methods development to identify and exclude defective proviruses from viral-load, bNAb-sensitivity, and dru…

It is well-established that defective HIV proviruses accumulate rapidly during acute HIV infection and constitute more than ninety percent of all proviruses in people living with HIV, regardless of the timing of antiretroviral therapy (ART) initiation. Moreover, recent evidence suggests that the…

Funding Source

Agency: National Institutes of Health

Sub-agency: National Institute of Allergy and Infectious Diseases

Awards & funding

Total Funding: $500,000

Award Ceiling: $500,000

Award Amount: $500,000

Eligibility

Higher Education Institutions – Private Institutions of Higher Education

Nonprofits (Other than Institutions of Higher Education) – without 501(c)(3) IRS Status

For-Profit Organizations – Other than Small Businesses

County Governments

City or Township Governments

Special District Governments

Native American Tribal Organizations (other than Federally recognized tribal governments)

Federal Government – Eligible Agencies of the Federal Government

U.S. Territory or Possession

Independent School Districts

Public Housing Authorities/Indian Housing Authorities

Faith-based or Community-based Organizations

Regional Organizations

Non-domestic (non-U.S.) Entities (Foreign Organizations)

Non-domestic (non-U.S.) components of U.S. Organizations

Foreign components (as defined in NIH Grants Policy Statement) are allowed

Foreign eligibility: Non-domestic (non-U.S.) entities (foreign organizations) are eligible to apply. Non-domestic components of U.S. organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
Required registrations (must be…

Dates

Opportunity Released: December 9, 2024

Expiration Date: February 19, 2026

Supporting links

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