Role of Defective Proviruses in HIV Persistence (R01 Clinical Trial Not Allowed)
This R01 NOFO seeks research using human samples to define how abundant, replication-incompetent (defective) HIV proviruses—which can express viral RNA and protein—affect immune activation, reservoir dynamics, post-treatment control, and responses to HIV cure strategies. It also supports methods development to identify and exclude defective proviruses from viral-load, bNAb-sensitivity, and dru…
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