This NIH Parent R01 funds investigator-initiated, discrete research projects that align with the missions of NIH Institutes and Centers using the R01 mechanism. Applications proposing clinical trials are not accepted; applicants should identify and contact relevant ICs to confirm fit and interest.

The NIH Research Project Grant supports a discrete, specified, circumscribed project in scientific areas that represent the investigators specific interests and competencies and that fall within the mission of the participating NIH Institutes and Centers (ICs). The R01 is the original, and historically the oldest, grant mechanism used by the NIH to support health-related research and development.

Research grant applications are assigned to participating ICs based on receipt and referral guidelines and applications may be assigned to multiple participating ICs with related research interests. Applicants are encouraged to identify a participating IC that supports their area of research via the R01 IC-Specific Scientific Interests and Contact website and contact Scientific/Research staff from relevant ICs to inquire about their interest in supporting the proposed research project.

This Notice of Funding Opportunity does not accept applications proposing clinical trial(s).

For specific information about the mission of each NIH IC, visit the List of NIH Institutes, Centers, and Offices website.

See Section VIII. Other Information for award authorities and regulations.