forecast DHA26BZ01-DV005

Direct-to-Phase II: Small Molecules with Broad-Spectrum Antifungal Activity for Safe Human Use

This opportunity solicits Direct-to-Phase II proposals to advance small-molecule candidates that are ready for Phase II testing, focusing on broad-spectrum, fungicidal activity against clinically relevant fungal pathogens while minimizing toxicity to humans. The primary goal is to identify a safe antifungal small molecule suitable for patient use and capable of achieving FDA clearance.

This topic is intended for technology proven ready to move directly into Phase II and accepts Direct to Phase II proposals only. The proposed research will focus on identifying compounds with broad-spectrum activity against clinically relevant fungal pathogens while minimizing toxicity to humans…

Funding Source

Agency: U.S. Department of Defense
Phase: Phase D2PII
Phase: Phase II
Phase: Phase SPII

Dates

Topic Opens: May 6, 2026
Topic Closes: June 3, 2026

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