Scout | PAR-25-300: Targeting HIV-1 Envelope on Infected Cell Surfaces to Enable Immune Elimination (R01, No Clinical Trial)

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grant PAR-25-300

Targeting HIV-1 Envelope on Infected Cell Surfaces to Enable Immune Elimination (R01, No Clinical Trial)

Summary

This R01 NOFO seeks basic and translational research to understand how HIV-1 envelope (Env) is regulated on the surface of infected cells and to develop or optimize Env-targeting biologics (engineered antibodies, T/NK cell engagers, CAR T/NK cells) that enhance immune recognition and killing. Projects may use advanced imaging and in situ structural methods to define Env surface dynamics, the s…

HIV-1 infected cells are not efficiently eliminated by host immune responses despite antiviral treatment that suppresses viral replication and spread. The HIV-1 envelope glycoprotein (Env) is the only viral protein expressed on the cell surface. HIV-1 has evolved ways to prevent Env-expressing c…

Funding Source

Agency: National Institutes of Health

Sub-agency: National Institute of Allergy and Infectious Diseases

Eligibility

Private Institutions of Higher Education

Nonprofits without 501(c)(3) IRS Status (Other than Institutions of Higher Education)

For-Profit Organizations (All)

For-Profit Organizations (Other than Small Businesses)

Federal Governments (All)

U.S. Territory or Possession

Local Governments (All)

County Governments

City or Township Governments

Special District Governments

Native American Tribal Organizations (other than Federally recognized tribal governments)

Independent School Districts

Public Housing Authorities/Indian Housing Authorities

Faith-based or Community-based Organizations

Regional Organizations

Non-domestic (non-U.S.) Entities (Foreign Organizations)

Non-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply. Non-domestic (non-U.S.) components of U.S. organizations are also eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
Required registrations (must be comp…

Dates

Opportunity Released: December 2, 2024

Expiration Date: February 19, 2026

Supporting links

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