NCATS SPoT Initiative: Precision drug targeting using microphysiological systems
NCATS is launching the Selective Precision Targeting (SPoT) initiative to develop and test mechanisms for delivering therapeutics to hard-to-reach body locations. The program focuses on optimizing targeting of nanoparticles, extracellular vesicles, and/or focused ultrasound, assessing biodistribution and off-target effects with multi-organ MPS models, and demonstrating functional cargo activit…
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