Investigating Distinct and Overlapping Mechanisms in TDP-43 Proteinopathies, including in LATE, FTD and other ADRDs (R01 - Clinical Trial Not Allowed)
This grant opportunity aims to explore the underlying mechanisms and causal relationships of TDP-43 protein-related diseases. It focuses on understanding how TDP-43 interacts with other diseases, like those involving the TMEM106B protein, and compares TDP-43 related conditions such as LATE, FTD, and ALS, both with and without Alzheimer’s disease neuropathologic changes. Research could include …
This FOA would support establishing deeper mechanistic insight and causal relationships between TDP-43 pathology and phenotypic outcomes, as well as mechanistic interactions between TDP-43 and other co-pathologies, such TMEM106B. Additionally, it would include comparisons (including mechanistic,…
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