Scout | Investigating Distinct and Overlapping Mechanisms in TDP-43 Proteinopathies, including in LATE, FTD and other ADRDs (R01

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Investigating Distinct and Overlapping Mechanisms in TDP-43 Proteinopathies, including in LATE, FTD and other ADRDs (R01 - Clinical Trial Not Allowed)

This grant opportunity aims to explore the underlying mechanisms and causal relationships of TDP-43 protein-related diseases. It focuses on understanding how TDP-43 interacts with other diseases, like those involving the TMEM106B protein, and compares TDP-43 related conditions such as LATE, FTD, and ALS, both with and without Alzheimer’s disease neuropathologic changes. Research could include …

Source

Agency: National Institutes of Health

Program: SBIR

Award

Award Ceiling: $500,000

Funding Amount: $500,000

Keywords

TDP-43 proteinopathy

mechanistic insights

LATE

FTD

ADRDs

neuropathology

genetic studies

molecular interactions

causal relationships

TMEM106B

clinical research.

Supporting Links

Documents

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