Translational Bioinformatics and Experimental Approaches to Advance Drug Repositioning and Combination Therapy Development for Alzheimer’s Disease and Related Dementias (R01 Clinical Trial Not Allowed)
This R01 funds rigorous preclinical proof-of-concept testing of drug candidates and drug combinations identified by data-driven/translational bioinformatics for treatment or prevention of Alzheimer’s disease and related dementias. Projects should use mouse or cell-based models (e.g., iPSCs, organoids), follow NIH rigor and ARRIVE guidelines, prioritize candidates (including failed Phase II/III…
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