Scout | NCATS R21: Preclinical proof-of-concept efficacy studies for rare-disease therapies (includes PK/PD)

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NCATS R21: Preclinical proof-of-concept efficacy studies for rare-disease therapies (includes PK/PD)

NCATS invites R21 applications to run rigorous efficacy studies of a potential therapeutic in an established, validated rare-disease preclinical model, showing proof of concept for further development. Projects should include pharmacokinetic and pharmacodynamic measures alongside efficacy endpoints, and may support additional PK if feasible. Applicants must include a plan for a rare-disease st…

Source

Agency: National Institutes of Health

Sub-agency: National Center for Advancing Translational Sciences

Award

Total Funding: $1.2M

Award Ceiling: $200,000

Dates

Opportunity Released: December 6, 2024

Eligibility

government

industry:research

nonprofit

small_business

tribal

university

Higher Education Institution — Public/State-Controlled Institutions of Higher Education

Nonprofit Organization — Nonprofit (Other Than Institutions of Higher Education)

For-Profit Organization — Small Business

Local Government

Indian/Native American Tribal Government — Federally Recognized

Keywords

rare diseases

preclinical efficacy

pk pd

r21 clinical trial not allowed

validated models

therapeutic development

ncats

proof of concept

Supporting Links

Documents

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