Scout | PAR-25-226: Seamless Early-Stage Clinical Drug Development (Phase 1 to 2a) for Novel therapeutic Agents for the Spectrum of Alzheimer's Disease (AD) and AD-related Dementias (ADRD) (UG3/UH3 Clinical Trial Required)

grant PAR-25-226

Seamless Early-Stage Clinical Drug Development (Phase 1 to 2a) for Novel therapeutic Agents for the Spectrum of Alzheimer's Disease (AD) and AD-related Dementias (ADRD) (UG3/UH3 Clinical Trial Required)

Summary

This grant opportunity focuses on supporting early-stage clinical trials for new treatments targeting Alzheimer's disease and related dementias. It combines initial phase 1 and early phase 1b/2a trials into one process. Eligible interventions should target mechanisms other than amyloid and tau proteins and aim to improve cognitive and/or neuropsychiatric symptoms across different stages of the…

The biggest risk factor for Alzheimer's disease (AD) is age. AD is the most common cause of dementia in those aged 65 and older. As populations age worldwide, this disorder, as well as AD-related dementias (ADRD), will reach epidemic proportions even in best-case scenarios, with an enormous huma…

Funding Source

Agency: National Institutes of Health

Sub-agency: National Institute on Aging

Eligibility

Higher Education Institutions: Private Institutions of Higher Education

Nonprofit Organizations (Other than Institutions of Higher Education): without 501(c)(3) IRS Status

Independent School Districts

For-Profit Organizations: For-Profit Organizations (Other than Small Businesses)

Public Housing Authorities/Indian Housing Authorities

Native American Tribal Organizations (other than Federally recognized tribal governments)

Eligible Agencies of the Federal Government

U.S. Territory or Possession

Faith-based or Community-based Organizations

Regional Organizations

Non-domestic (non-U.S.) Entities (Foreign Organizations)

Non-domestic (non-U.S.) components of U.S. Organizations

Foreign entities and foreign components: Non-domestic (non-U.S.) entities (foreign organizations) are eligible to apply. Non-domestic (non-U.S.) components of U.S. organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Dates

Opportunity Released: November 22, 2024

Supporting links

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