Mechanistic Investigations into ADRD Associated Protein Structures in Biological Settings (R01 - Clinical Trial Not Allowed)
This grant opportunity focuses on advancing structural biology techniques to characterize large protein assemblies related to Alzheimer's Disease (AD) and Alzheimer's Disease-Related Dementias (ADRD). Traditional methods often use purified samples, which may not accurately represent the diverse protein structures found in living organisms. New advancements allow for studying these assemblies i…
Advances in structural biology have enabled the characterization of large protein assemblies that are linked to AD/ADRD pathology. However, most structural biology approaches require purified samples from cells and tissues or use recombinant bacterial proteins. The derived structures using ex-vi…
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